Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP [9] It is available as a generic medication. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). apical ROMK/Na channels coupled with basolateral Na+/K ATPases). Chlorthalidone has a much longer half-life compared to HCTZ (mg/mg) (44 hours, chlorthalidone vs. 12 hours, hydrochlorothiazide) and indapamide is 10 times more potent. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. [23] A Cochrane review found tentative evidence that thiazide exposure was associated with a reduced risk of hip fracture. you'll often start with a thiazide diuretic, such as: * chlorthalidone (hygroton) * chlorothiazide (diuril) * hydrochlorothiazide or hctz (esidrix, hydrodiuril, microzide) * indapamide (lozol) * chlorthalidone systemic. Definition of chlorthalidone in the Definitions.net dictionary. a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension. Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. National Center for Biotechnology Information. Chlorthalidone systemic is used in the treatment of: Edema. 14, pp. [1] It is also used to prevent calcium-based kidney stones. It helps the kidney to get rid of unwanted water and salt from the body into the urine. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. Liver disease: There is a risk of precipitating hepatic encephalopathy in patients with liver cirrhosis and ascites. [30], Some reviews have found a similar risk as hydrochlorothiazide,[7][8] while other reviews found a higher risk of side effects.[5][6]. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. This medication is used to treat high blood pressure (hypertension). Thalitone has a different formulation and is more potent. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. Drug information provided by: IBM Micromedex. [1] It is specifically a thiazide-like diuretic. Disclaimer - All information and content on this site are for information and educational purposes only. US Brand Name. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. Drug class (es): thiazide diuretics. Description and Brand Names. Chlorthalidone Tablets, USP are available containing 25 mg or 50 mg of Chlorthalidone, USP. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. [15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. More Info about Chlorthalidone. By blocking sodium ion resorption in the distal convoluted tubule, chlortalidone induces an increase in excretion of sodium ion in urine (natriuresis). [1] Some recommend chlortalidone over hydrochlorothiazide. Diabetes and hypertension (high blood pressure) are significant health problems worldwide, but like cardiac disease and fatty liver disease, people of Indian origin are disproportionately affected. It increases the amount of urine you make, especially when you first start the medication. [1][2] In high blood pressure it is a preferred initial treatment. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. Documented hypersensitivity to chlorthalidone or sulfonamides. Contraindications. Effects generally begin within three hours and last for up to three days. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … [1][2][3] Other side effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. Highlights for chlorthalidone. Summary. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. [5][12] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity. Chlorthalidone manufacturer,Chlorthalidone 15mg,clonidine hcl 0.1mg,Chlorthalidone 100mg,Chlorthalidone 12.5mg Largest Generic Manufacturer,Formula,producing With chemical method according to the present invention Suppliers List,Molecular Structure,Weight,IUPAC,Synonyms for Chlorthalidone "Chlorthalidone." [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. What is chlorthalidone (Hygroton, Thalitone)? [1] Effects generally begin within three hours and last for up to three days. Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. [19] Chlortalidone is superior to angiotensin converting enzyme Inhibitors or angiotensin II receptor blockers for inducing regression of enlargement of the left ventricle, which is the main pumping chamber of the heart. ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. Chlorothiazide systemic is used in the treatment of: Edema. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … Thalitone; Descriptions. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. Chlorthalidone is an oral antihypertensive/diuretic. Chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg wi MedChem Express HY-15833: Membrane Tranporter/Ion Channel MedChem Express HY-15833 Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. [1] It is taken by mouth. High blood pressure adds to the workload of the heart and arteries. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Clonidine and chlorthalidone combinations are used in the treatment of high blood pressure (hypertension). It also helps to relax the blood vessels so that blood can flow more easily. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. [46] Chlortalidone may suppress lactation, and has been used for this indication. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. Brand names: Diuril, Diuril Sodium. Chlortalidone is a diuretic, which means it helps your body get rid of extra salt (sodium) and water.It works by increasing the amount of urine (pee) you make. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. In high blood pressure it is a preferred initial treatment. [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. Chlorthalidone is a "water pill " (diuretic). Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. 2. Anuria. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. Chlorthalidone is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. chlorothiazide systemic. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. The most common adverse reaction in adults is diarrhea. Stones in the urinary system can form in the kidneys and can sometimes travel down towards the bladder to give rise to acute colics. 100 Description and Brand Names. The frequency and severity of these adverse effects is much reduced when chlortalidone is used at lower doses (e.g., 12.5 mg per day). PubChem Compound Database; CID=2732, enlargement of the left ventricle of the heart, "Chlorthalidone Monograph for Professionals", "Thiazide-associated hyponatremia in the elderly: what the clinician needs to know", "Treatment of Resistant and Refractory Hypertension", "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis", "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis", "Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic", "Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline", "Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD", "Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone", "Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial", "Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline", "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis", "A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. [42] Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. More effective than hydrochlorothiazide for lowering urine calcium levels and is excreted in urine, reducing risk... As unchanged drug medication is used in the treatment of chlorthalidone trade name diabetes insipidus a brand-name.! 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